By Silvio Garattini and Parkhurst A. Shore (Eds.)
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Additional info for Advances in Pharmacology
Collier, 196313) (Fig. 8). Rabbits also react to the administration of bradykinin with bronchoconstriction. , 1962b). Bradykinin is ineffective when given in aerosol to guinea pigs or healthy wen. Asthmatic patients, however, are very sensitive to bradykinin aerosol (Melon and Lecomte, 1962), especially after consuming hard liquor (Schnaps) (H. Herxheimer and Streseniann, 1961, 1963; Stresemann, 1963). Some of these patients reacted to the peptide with an exceptionally violent attack. 9. Interaction with Other Agents Kinins or kallikrein can act either synergistically with some other pharmacologically active agents, or they can antagonize them (Section I1,C).
Used a denatured substrate. Another source of discrepancy niighh have been the difference in temperature during the handling of plasma. , 1965). A decrease in the kininogen level in blood during delivery was also observed by Periti et al. (1962). , 1963). , 1963a). , 1950), in colostrum (Werle, 1960; Guth, 1959), in bone marrow (Werle and Preisser, 1956), and in lymph (Schachter, 1960), but not in the cellular elements of blood. Bradykininogen niay originate from the liver, since CCI, treatment orhepatectomy decreases its level in rabbits (Diniz and Carvalho, 1963).
Kinins are frequently assayed on isolated smooth muscle preparations. The rat uterus in estrus is the most sensitive organ. Bradykinin causes the characteristically slow contraction of the guinea pig intestine, which inspired its name. This stimulation of smooth muscles is not blocked by specific compounds which would eliminate the effect of acetylcholine, histamine, or serotonin. Bradykinin relaxes the isolated HYPOTENSWE PEPTIDES 27 rahhit intestine lwiefly; this is followed by contraction. , 1964).