By Lesley-Ann Giddings, David J. Newman
A dialogue of the chemical substances produced via organisms residing below severe stipulations which can have strength as medicinal drugs or ends up in novel medicines for human use. This SpringerBrief offers with bioactive fabrics from terrestrial extremophiles.
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Additional info for Bioactive Compounds from Terrestrial Extremophiles
2012), isolated from Actinopolyspora erythraea YIM 90600 and Streptomyces sp. 9). There is significant diversity that exists among halophiles isolated from the same environment. Halophiles isolated from microorganisms collected from the same site, such as the sediment and water of the Weihai Solar Saltern in China, have led to the identification of new bioactive metabolites. For example, Chen and coworkers isolated 45 moderately halophilic eubacterial strains from the sediment and water of the Weihai Solar Saltern in China (Chen et al.
Halodurans C-125 isolated from soil and identified genes involved in the biosynthesis of a lantibiotic (Lawton et al. 2007). Using assay-guided fractionation, haloduracin, a complex two-peptide lantibiotic composed of posttranslationally modified Halα and Halβ, was observed to have antimicrobial activity against Lactococcus lactis HP and inhibit the spore outgrowth of B. anthacis. Antibiotic activity was further confirmed by mutagenesis of the Hal genes involved in the expression of these peptides.
Lactonamycin Z 109 has unique structural features that include both a naphtha[e]isoindole ring system and an oxygen-rich perhydrofuran–furanone ring system with a labile tertiary methoxy group. Compound 109 exhibited weak antibiotic activity against Grampositive eubacteria with inhibition zones from 7 to 24 mm at a concentration of 1 mg/ml. 7 µM, respectively. 79 µM (Matsumoto et al. 1999). Lactonamycin also exhibited potent antibiotic activity against various multidrug-resistant eubacteria, indicating that the modified sugar may be important for antibacterial activity.