Download Biochemistry and Biology of Coronaviruses by Lawrence S. Sturman (auth.), V. ter Meulen, S. Siddell, H. PDF

By Lawrence S. Sturman (auth.), V. ter Meulen, S. Siddell, H. Wege (eds.)

This booklet is the results of a world symposium held on the Institute of Virology and Immunobiology of the-University of WUrzburg, Germany, in October 1980. The reason of this symposium was once to supply a chance to check the knowledge on coronavirus constitution and duplicate­ tion in addition to to debate mechanisms of pathogenesis. For over a decade coronaviruses were famous as an enormous crew of viruses that are chargeable for numerous illnesses of medical value in animals and guy. lately new and engaging facts at the molecular biology and pathogenesis of coronaviruses became to be had and this led us to arrange this assembly. The uniformity and variety during this virus workforce was once evaluated from a molecular standpoint and the replication of coronaviruses looks to contain elements that could be specific for this virus staff. also, not like different optimistic strand RNA viruses it grew to become transparent that coronaviruses conveniently determine continual infections within the host, a phenomenon that may result in the various subacute or power issues manifested in the course of coronavirus an infection. This quantity provides a chain of articles established upon the medical presentation given on the symposium. additionally, there are articles by means of B. W. J. Mahy and D. A. J. Tyrrell which summarize the present country of paintings about the biochemistry and biology of coronaviruses, respective­ ly. We think this e-book may be of curiosity to all virologists and especially to either validated employees and novices to this box. V.

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Sample text

Strain 229E is readily identified by serum neutralization (SN) tests in various cell cultures. 23 ,26,36 In addition, sensitive indirect hemagglutination (IRA) and immune-adherence hemagglutination (lARA) tests were developed to measure serum antibodies. ). 3 x 10 5 • The purity of the virus was confirmed by immunologic procedures, density gradient centrifugation, electron microscopy, and analytical procedures. 30 Electron microscopy at low and high magnifications showed very clean fields of particles exhibiting the pleomorphism typical of this virus.

Polypeptides form the surface projections, VP 51 corresponding to VP 50 of HCV 229E comprises the RNP, and the small mol. wt. glycopolypeptide VP 33 forms the membrane polypeptide (3,11,13). ANTIGENIC RELATIONSHIPS Previous studies on the antigenic relationships of coronaviruses, using a variety of techniques, have produced a confusing pattern of interrelationships (14,19). A recent comprehensive study by Pederson et al (17) has shown that mammalian coronaviruses can be grouped into at least two main antigenic groups by fluorescent antibody studies.

MACNAUGHTON Table 4 Antigenic groups of selected coronaviruses by ELISA Group 1 IBV strains Mass, Beau and Conn Group 2 RCV strains 229E, PR, KI, and TO Group 3 RCV strain OC43 and MHV strain 3 The classification of RCV strains AD, RO, GI, PA and RO is unclear at present. these studies all used RCV OC43 grown in suckling mouse brain. Thus, the coronaviruses studied can be grouped into at least three main antigenic groups by ELISA (Table 4), with the RCV strains AD, RO, GI, PA and RO probably being related to the RCV 229E group or RCV OC43.

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