Download Biochemistry of Nickel by Robert P. Hausinger PDF

By Robert P. Hausinger

In this well timed monograph, the writer summarizes the quickly becoming physique of information concerning nickel via supplying a balanced dialogue of its destructive and helpful results. assurance features a heritage of nickel; the chemistry of nickel, descriptions of the 4 recognized enzymes which comprise nickel; and nickel metabolism in microbes, vegetation, and animals. Taken as a complete, Dr. Hausinger's paintings will spotlight key good points of this significant point and support outline destiny research.

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Extra resources for Biochemistry of Nickel

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Cotton, F. , 1980. , John Wiley & Sons, New York, pp. 783-798. Coyle, C. , and Stiefel, E. , 1988. The coordination chemistry of nickel: An introductory survey, in The Bioinorganic Chemistry oj'Nickel (J. R. ), VCH Publishers, New York, pp. 1-28. Dixon, N. , Blakeley, R. , 1980. 5). I. A simple dry ashing procedure for the microdetermination of trace metals in proteins. The nickel content of urease, Can. J. Biochem. 58:469-473. , 1990. Viability of the [Nim(SR)4 t unit in classical coordination compounds and in the nickel-sulfur center ofhydrogenases, J.

In the native enzyme, the nickel ions are not exchange-coupled in a binuclear center. A nearby histidine residue functions as a general base in catalysis. Furthermore, a cysteine residue is ionically coupled to an unidentified residue, and together they function as a proton donor during urea hydrolysis. Finally, a negatively charged group suspected to be at the active site is assigned to a carboxylate residue. Chapter 3 40 urea \ Hp ) > 1 carbamate~ 2Hp~ < Figure 3-3. Mechanism for urea hydrolysis.

1 BM at room temperature. 0023), true nickel(III) complexes exhibit anisotropic signals with significant deviations from the free-electron value. The EPR spectroscopic properties ofnickel(III) in an octahedral environment are provided as a specific example. To facilitate this discussion, energy level diagrams for compressed and elongated octahedral nickel species are provided in Fig. 2-4. In the lowest energy state, the seven d electrons of nickel(III) include three pairs occupying the lowest three orbitals and a lone electron in the next highest orbital.

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