By Gerhard Krauss
This all-new version of a best-selling textual content has been completely up to date to maintain speed with the quick growth in sign transduction research.
With didactic ability and readability, the molecular foundation of sign transduction, regulated gene expression, the mobile cycle, tumorigenesis and apoptosis is made obvious for everybody with a easy wisdom in biochemistry or molecular biology.
"Valuable updated info on biochemistry of sign transduction and regulation" (AFS)
"The transparent and didactic presentation makes it a textbook very priceless for college kids and researchers no longer accustomed to all facets of mobile regulation." (Biochemistry)
"This booklet is de facto books: rules and sign Transduction." (Drug Research)
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Extra resources for Biochemistry of Signal Transduction and Regulation
Compensates for the energy required to bend the DNA. An important contribution to the entire binding energy derives from the neutralization of the negative charge of the DNA. A neutralization of the negative charges on only one side of the phosphate backbone by a positively charged protein surface can lead to a bending of the DNA (see Fig. 13). The divergence of the DNA conformation from a rod-like structure is observed to a variable extent. The DNA can be slightly curved or abruptly kinked. If the DNA is only slightly bent, as observed for the nucleosome-bound DNA, then the required deformation energy is distributed over many base pairs.
Schematic display of the differing pattern of H-bond acceptors and donors in the Watson-Crick base pairs. The groups above the base pairs (above the line) are accessible in the major groove, and those below the line are accessible from the minor groove. 2 Protein-Nucleic Acid Interactions as a Basis for specific Gene Regulation 15 Fig. 12. Examples for the H-bonds in protein-nucleic acid complexes. A) H-bond contacts of the Q -repressor in complex with its operator sequence. After Jordan & Pabo, (1988).
The Zn2+ ions are drawn as spheres. MOLSCRIPT drawing (Kraulis, 1991). 8 1 The Regulation of Gene Expression Fig. 5. Zif268 in complex with DNA. a) specific H-bonds between amino acid side chains of fingers 1–3 of Zif268 and bases of the recognition sequence. The DNA is drawn as cylinders. The arrows emphasize contact with the major groove. b) periodic arrangement of fingers in the major groove of the DNA. According Pabo and Sauer (1992), with permission. 2 Protein-Nucleic Acid Interactions as a Basis for specific Gene Regulation 9 Zinc Finger of the Steroid Hormone Receptor The DNA-binding of the steroid hormone receptor occurs via an approx.