By Hongzhe Sun
Arsenic, antimony and bismuth, 3 comparable parts of crew 15, are all present in hint amounts in nature and feature attention-grabbing organic houses and makes use of. whereas arsenic is most popular as a poison - and certainly the infection of groundwater through arsenic is changing into a big illness in Asia - it additionally has makes use of for the remedy of blood melanoma and has lengthy been utilized in conventional chinese language medication. Antimony and bismuth compounds are utilized in the hospital for the therapy of parasitic and bacterial infections.Biological Chemistry of Arsenic, Antimony and Bismuth is an important assessment of the organic chemistry of those 3 parts, with contributions from a world panel of specialists. issues lined include:chemistry of As, Sb and Bibiological chemistry of arsenicbiological chemistry of Sb and Biarsenic and antimony speciation in environmental and organic samplesarsenic in conventional chinese language medicinearsenic in aquifersbiomethylation of As, Sb and Biuptake of metalloids through cellsbismuth complexes of porphyrins and their power in scientific applicationsHelicobacter pylori and bismuthmetabolism of arsenic trioxide in blood of the extreme promyelocytic leukemia patientsanticancer homes of As, Sb and Biradio-Bi in melanoma therapygenotoxicity of As, Sb and Bimetallomics as a brand new procedure for As, Sb and Bimetalloproteomics for As, Sb and BiBiological Chemistry of Arsenic, Antimony and Bismuth conveys the basic features of the bioinorganic chemistry of those 3 components, making this booklet a useful supplement to extra normal bioinorganic chemistry texts and extra really good topical reports. it's going to discover a position at the bookshelves of practitioners, researchers and scholars operating in bioinorganic chemistry and medicinal chemistry.
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Extra info for Biological Chemistry of Arsenic, Antimony and Bismuth
In some comparisons of the LC50 of sulfur containing arsenicals in cell culture, the values are often fairly similar to related trivalent arsenicals. For example, in human hepatocarcinoma HepG2 cells, DMMTA(V) was about 10 times more cytotoxic than DMA(V) . 7 for DMMTA(V), 571 for As(V) and 843 for DMA(V) . 9 for (DMTA(V) . 1 Cancer – MOA Binding to RSH Groups From the biochemically oriented world of individual arsenicals interacting with certain macromolecules, it is a long jump and multiple levels of biological organization to reach the adverse health consequences associated with arsenic exposure in humans such as black foot disease, increased cardiovascular risk, diabetes, cancer, toxicity and rarely death .
73. S. , Hoboken. 74. H. G. E. Stevens), Plenum, New York, pp. 71–110. 75. G. (1984) in: Chemical M€ ossbauer Spectroscopy (ed. H. Herber), Plenum, New York, pp. 319–342. 2 Arsenic’s Interactions with Macromolecules and its Relationship to Carcinogenesis Kirk T. S. 1 Introduction This book chapter presents selected aspects of arsenic biochemistry, some of the effects of arsenicals on biochemical endpoints, three possible modes of action (MOA) (binding, oxidative stress and DNA methylation) for arsenic causing human cancer, several of the connections between arsenic and carcinogenicity (epidemiological studies, animal studies and the use of arsenic in the treatment of leukaemia) and finally some sources of information for newcomers to this large and complex research area.
11) are the common forms of arsenic in marine organisms and are found to be nontoxic in mice and hamsters . In general, inorganic forms of arsenic have higher toxicity in humans than organoarsines , which are readily excreted [1, 9]. Antimony occurs most commonly as [Sb(OH)6]À, although it has also been postulated as Sb(OH)5ÁH2O in aqueous environments at pH > 4 . Under acidic conditions (pH 2), [SbO]þ or [Sb(OH)2]þ are found [12, 65], while at pH > 11, [Sb(OH)4]À is the dominant form .