Download Biopharmaceutics applications in drug development by Rajesh Krishna, Lawrence Yu PDF

By Rajesh Krishna, Lawrence Yu

Within the final 20 years, the self-discipline of biopharmaceutics has passed through substantial advances, relatively with reference to bioavailability and bioequivalence as they relate to product caliber and regulatory criteria of approval. Textbooks within the box haven't been in a position to stay alongside of the expansion of present and rising functions of regulatory points of biopharmaceutics. Biopharmaceutics purposes in Drug improvement fills this hole. This ebook introduces primary innovations, tools, and advances within the components of dissolution, absorption, and permeability and their key functions in dosage shape functionality. Case experiences are used to debate the functions of biopharmaceutic techniques within the improvement of winning medicinal drugs, with a particular specialise in the purposes of biopharmaceutic options within the improvement of profitable medicinal drugs. The ebook provides an built-in view in linking pharmaceutic to the organic results of drug items and leverages these for determination making in drug improvement.

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Cooperwood, J. , and Ko, D. H. (2002). Prodrug and antedrug: two diametrical approaches in designing safer drugs. Arch. Pharm. Res. 25:111–136. Lennernas, H. and Abrahamsson, B. (2005). The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension. J. Pharm. Pharmacol. 57:273–285. 24 N. P. Barbour and R. A. Lipper Leslie, E. , Deeley, R. , and Cole, S. P. (2005). Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense.

Hussain, M. , Smith, R. , and Sun, D. (2005). pH-dependent dissolution in vitro and absorption in vivo of weakly basic drugs: development of a canine model. Pharm. Res. 22:188–192. 1 Introduction Oral administration is still regarded as the most commonly accepted route of drug administration offering numerous advantages including convenience, ease of compliance, and cost-effectiveness. Not surprisingly, desirable oral bioavailability is one of the most important considerations for the successful development of bioactive molecules.

Res. 20:1149–1155. , and Hayashi, H. (1995). A new pharmacokinetic model including in vivo dissolution and gastrointestinal transit parameters. Biol. Pharm. Bull. 18:882–886. Johnson, K. C. and Swindell, A. C. (1996). Guidance in the setting of drug particle size specifications to minimize variability in absorption. Pharm. Res. 13:1795–1798. Jung, M. (2001). Antibody directed enzyme prodrug therapy (ADEPT) and related approaches for anticancer therapy. Mini. Rev. Med. Chem. 1:399–407. Kalgutkar, A.

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