Download Blood'Brain Barrier: Biology and Research Protocols (Methods by Sukriti Nag PDF

By Sukriti Nag

Univ. of Toronto, Canada. textual content presents the main points of chosen morphologic, permeability, delivery, in vitro, and molecular recommendations for BBB experiences. each one half is preceded through a evaluate emphasizing the benefits and pitfalls of specific concepts. Written for researchers in BBB. DNLM: Blood--Brain Barrier--physiology.

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P. (2000) Kinin B1 receptor expression and function on human brain endothelial cells. J. Neuropathol. Exp. Neurol. 59, 896–906. 18. , and Barclay, A. N. (1991) The MRC OX-47 antigen is a member of the immunoglobulin superfamily with an unusual transmembrane sequence. Eur. J. Immunol. 21, 671–679. 19. Sternberger, N. , and Sternberger, L. A. (1987) Blood-brain barrier protein recognized by monoclonal antibody. Proc. Natl. Acad. Sci. USA 84, 8169–8173. 22 Nag 20. Cassella, J. , Lawrenson, J. , and Firth, J.

Endothelial cells produce transforming growth factor (254), VEGF (255), endothelin-1 (256,257), and platelet-derived growth factor, all of which have been shown to influence pericyte function. Transforming growth factor inhibits pericyte growth, whereas VEGF stimulates pericyte proliferation in vitro. Endothelin-1 stimulates pericyte contraction and is a pericyte mitogen in vitro. The origin of platelet-derived growth factor from endothelial cells is less certain. However, in the absence of this agent, pericytes do not develop (258), hence it is thought to serve as a migration and/or differentiation signal (259,260).

Biochem. 137, 455–465. 217. , and Chung, A. E. (1981) Entactin, a novel basal laminaassociated sulfated glycoprotein. J. Biol. Chem. 256, 5209–5214. 218. Kefalides, N. , and Clark, C. C. (1979) Biochemistry and metabolism of basement membranes. Int. Rev. Cytol. 61, 167–228. 219. Vorbrodt, A. W. (1993) Morphological evidence of the functional polarization of brain microvascular endothelium. In The Blood-Brain Barrier. Cellular and Molecular Biology. (Pardridge, W. ), Raven, New York, pp. 137–164.

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