Download Toxicology of the Kidney, 3rd Edition (Target Organ by Joan B. Tarloff, Lawrence H. Lash PDF

By Joan B. Tarloff, Lawrence H. Lash

The kidney performs a necessary function in convinced endocrine features. Abnormalities as a result of poisonous chemical compounds or different interventions may have profound results on those services and for that reason, on overall features. up to date to mirror the newest learn within the box, Toxicology of the Kidney, 3rd version specializes in the correlation among the anatomy, biochemistry, and body structure of the kidney. The textual content seeks to give an explanation for how this correlation is said to innovations of scientific nephrotoxicity, and renal failure in people and the way animal versions can be utilized to appreciate the mechanisms of human renal ailment.

Show description

Read or Download Toxicology of the Kidney, 3rd Edition (Target Organ Toxicology Series) PDF

Best toxicology books

Regulatory Toxicology

This sensible source offers toxicologists and scientists with crucial details at the rules that govern their jobs and items. Regulatory Toxicology additionally covers the clinical and ancient underpinnings of these laws. each one bankruptcy offers a grounding within the historic occasions that resulted in the advance of unique laws and significant next adjustments in laws.

Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases

Lead Compounds from Medicinal crops for the remedy of Neurodegenerative ailments is the second one quantity within the sequence, Pharmaceutical Leads from Medicinal crops. This e-book comprises key pharmacological and chemical proof to help the choice of promising pre-clinical applicants for the remedy of neurodegenerative illnesses.

Manganese in Health and Disease

Manganese within the nutrition is nutritionally crucial for regular physiologic functioning. even if, over the top publicity to manganese has been linked to developmental, neurodegenerative and different issues. The e-book comprehensively covers the toxicology of manganese. major investigators supply views from toxicology, neuroscience, foodstuff, molecular biology and possibility evaluation disciplines and chapters disguise the toxicokinetics, toxicodynamic interactions and future health results of manganese, in addition to its strength function in neurodegenerative illnesses.

Making the Most of Haccp: Learning from Others’ Experience

The possibility research and important keep watch over element (HACCP) process has now turn into typically authorized because the key defense administration approach for the foodstuff around the globe. while there are various courses on its ideas and techniques of implementation, there are really few at the event of these who've truly carried out HACCP structures in perform and what will be learnt from that have.

Extra info for Toxicology of the Kidney, 3rd Edition (Target Organ Toxicology Series)

Example text

1981). The number of intercalated cells progressively decreases as the OMCD descends from the outer stripe to the inner medulla. Physiology The primary function of the OMCD is urinary acidification. , 1983). , 1987). , 1987). , 1986). , 2001). 22 Transmission electron micrograph of rat outer medullary collecting duct from the outer stripe (OMCDo). In the OMCDo, two cell types are present: the principal cell and the intercalated cell. Compared with intercalated cells, the principal cell (center) has a pale cytoplasm, few mitochondria, a smooth apical surface.

1978). 1). , 1978). 15 Scanning electron micrograph of rat cortical thick Toxicology of the kidney 30 ascending limb of the loop of Henle. Both rough and smooth type thick ascending limb cells are present. In both cell types, the cell borders exhibit an undulating path; in this example the undulations of the cell borders are few and shallow, typical of the thick ascending limb as it nears the distal convoluted tubule. In deeper thick ascending limb segments, the frequency and amplitude of the undulations are much greater.

21 Transmission electron micrograph of a Type B intercalated cell in a cortical collecting duct from rat kidney. The type B intercalated cell under basal conditions is characterized by a smooth apical surface, dark cytoplasm, an eccentric nucleus, small cytoplasmic vesicles throughout the cell, a subapical band of cytoplasm that is Toxicology of the kidney 38 relatively free of vesicles, and numerous, clustered mitochondria. , 2003). Physiology The collecting duct is responsible for regulating the final composition of urine.

Download PDF sample

Rated 4.87 of 5 – based on 37 votes