By Joan B. Tarloff, Lawrence H. Lash
The kidney performs a necessary function in convinced endocrine features. Abnormalities as a result of poisonous chemical compounds or different interventions may have profound results on those services and for that reason, on overall features. up to date to mirror the newest learn within the box, Toxicology of the Kidney, 3rd version specializes in the correlation among the anatomy, biochemistry, and body structure of the kidney. The textual content seeks to give an explanation for how this correlation is said to innovations of scientific nephrotoxicity, and renal failure in people and the way animal versions can be utilized to appreciate the mechanisms of human renal ailment.
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Extra info for Toxicology of the Kidney, 3rd Edition (Target Organ Toxicology Series)
1981). The number of intercalated cells progressively decreases as the OMCD descends from the outer stripe to the inner medulla. Physiology The primary function of the OMCD is urinary acidification. , 1983). , 1987). , 1987). , 1986). , 2001). 22 Transmission electron micrograph of rat outer medullary collecting duct from the outer stripe (OMCDo). In the OMCDo, two cell types are present: the principal cell and the intercalated cell. Compared with intercalated cells, the principal cell (center) has a pale cytoplasm, few mitochondria, a smooth apical surface.
1978). 1). , 1978). 15 Scanning electron micrograph of rat cortical thick Toxicology of the kidney 30 ascending limb of the loop of Henle. Both rough and smooth type thick ascending limb cells are present. In both cell types, the cell borders exhibit an undulating path; in this example the undulations of the cell borders are few and shallow, typical of the thick ascending limb as it nears the distal convoluted tubule. In deeper thick ascending limb segments, the frequency and amplitude of the undulations are much greater.
21 Transmission electron micrograph of a Type B intercalated cell in a cortical collecting duct from rat kidney. The type B intercalated cell under basal conditions is characterized by a smooth apical surface, dark cytoplasm, an eccentric nucleus, small cytoplasmic vesicles throughout the cell, a subapical band of cytoplasm that is Toxicology of the kidney 38 relatively free of vesicles, and numerous, clustered mitochondria. , 2003). Physiology The collecting duct is responsible for regulating the final composition of urine.